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Synthesis of homogenous site-selectively glycosylated proteins

Swanwick, Richard S., Daines, Alison M., Flitsch, Sabine L. and Allemann, Rudolf Konrad 2005. Synthesis of homogenous site-selectively glycosylated proteins. Organic & Biomolecular Chemistry 3 (4) , pp. 572-574. 10.1039/b417133k

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Abstract

Apparently homogenous glycoproteins can be synthesised in good yield by a combination of site directed mutagenesis, a highly flexible but selective chemical derivatisation and efficient purification through the use of glycosyl thiosulfonates such as 2-((biotinoyl)-amino)-ethyl methanethiosulfonate.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
Publisher: RSC Publications
ISSN: 1477-0520
Last Modified: 04 Jun 2017 02:54
URI: http://orca.cf.ac.uk/id/eprint/13488

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