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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: 'AbSeS', a multinational observational cohort study and ESICM trials croup project

Blot, Stijn, Antonelli, Massimo, Arvaniti, Kostoula, Blot, Koen, Creagh-Brown, Ben, de Lange, Dylan, De Waele, Jan, Deschepper, Mieke, Dikmen, Yalim, Dimopoulos, George, Eckmann, Christian, Francois, Guy, Girardis, Massimo, Koulenti, Despoina, Labeau, Sonia, Lipman, Jeffrey, Lipovestky, Fernando, Maseda, Emilio, Montravers, Philippe, Mikstacki, Adam, Paiva, Jose-Artur, Pereyra, Cecilia, Rello, Jordi, Timsit, Jean-Francois, Vogelaers, Dirk, Lamrous, Amin, Rezende-Neto, Joao, Cardenas, Yenny, Vymazal, Tomas, Fjeldsoee-Nielsen, Hans, Kott, Matthias, Kostoula, Arvaniti, Javeri, Yash, Einav, Sharon, Umezawa Makikado, Luis Daniel, Tomescu, Dana, Gritsan, Alexey, Jovanovic, Bojan, Venkatesan, Kumaresh, Mirkovic, Tomislav, Creagh-Brown, Benedict, Emmerich, Monica, Canale, Mariana, Silvina Dietz, Lorena, Ilutovich, Santiago, Sanchez Minope, John Thomas, Baldomera Silva, Ramona, Alexis Montenegro, Martin, Martin, Patricio, Saul, Pablo, Chediack, Viviana, Sutton, Giselle, Couce, Rocio, Balasini, Carina, Gonzalez, Susana, Lascar, Florencia Maria, Jorge Descotte, Emiliano, Soledad Gumiela, Natalia, Alejandra Pino, Carina, Cesio, Cristian, Valgolio, Emanuel, Cunto, Eleonora, Dominguez, Cecilia, Funes Nelson, Nydia, Martin Abegao, Esteban, Christian Pozo, Norberto, Bianchi, Luciana, Correger, Enrique, Laura Pastorino, Maria, Aurora Miyazaki, Erica, Grubissich, Nicolas, Garcia, Mariel, Bonetto, Natalia, Elizabeth Quevedo, Noelia, Delia Gomez, Cristina, Queti, Felipe, Gonzalez Estevarena, Luis, Cruz, Godoy, Fernandez, Ruben, Santolaya, Ignacio, Grangeat, Sergio Hugo, Doglia, Juan, Zakalik, Graciela, Pellegrini, Carlos, Monserrat Lloria, Maria, Esteban Chacon, Mercedes, Fumale, Mariela, Leguizamon, Mariela, Beatriz Hidalgo, Irene, Julian Tiranti, Roberto, Capponi, Paola, Tita, Agustin, Cardonnet, Luis, Bettini, Lisandro, Ramos, Agnel, Lovesio, Luciano, Miriam Miranda, Edith, Beatriz Farfan, Angelica, Tolosa, Carina, Segura, Lise, Bellocchio, Adelina, Alvarez, Brian, Manzur, Adriana, 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Marin, Jorge, Sanchez-Zamora, Purificacion, Vallverdu Vidal, Montserrat, Flores Gonzalez, Jesus, Salinas, Irene, Hermosa, Cecilia, Martinez-Sagasti, Fernando, Domingo-Marin, Sara, Abril Victorino, Johanna, Garcia-Alvarez, Raquel, Lopez-Arcas Calleja, Pablo, de la Torre-Prados, Maria-Victoria, Vidal-Cortes, Pablo, del Rio-Carbajo, Lorena, Izura, Javier, Minguez, Victoria, Trenado Alvarez, Josep, Parera Prous, Anna, Paz, Daniel, Roche-Campo, Ferran, Aguilar, Gerardo, Belda, Javier, Rico-Feijoo, Jesus, Aldecoa, Cesat, Zalba-Etayo, Begona, Lang, Martin, Dullenkopf, Alexander, Trongtrakul, Konlawij, Chtsomkasem, Anusang, Akbas, Turkay, Unal, Mustafa Necmettin, Ozcelik, Menekse, Gumus, Ayca, Ramazanoglu, Atilla, Memis, Dilek, Mehmet, Inal, Urkmez, Seval, Ozgultekin, Asu, Demirkiran, Oktay, Aslan, Nesrin Ahu, Kizilaslan, Deniz, Kahveci, Ferda, Unlu, Nurdan, Ozkan, Zeynep, Kaye, Callum, Jansen, Jan, O'Neill, Orla, Nutt, Christopher, Jha, Rajeev, Hooker, Nicolas, Grecu, Irina, Petridou, Christina, Shyamsundar, Murali, McNamee, Lia, Trinder, John, Hagan, Samantha, Kelly, Catriona, Silversides, Jonathon, Groba, Casiano Barrera, Boyd, Owen, Bhowmick, Kaushik, Humphreys, Sally, Summers, Charlotte, Polgarova, Petra, Margarson, Michael, Dickens, Justin, Pearson, Suzanne, Chinery, Elaine, Hemmings, Noel, O'Kane, Sinead, Austin, Pauline, Cole, Stephen, Plowright, Catherine, Box, Roberta, Wright, Christopher, Young, Lorna, Montague, Laura, Parker, Robert, Morton, Ben, Ostermann, Marlies, Bilinska, Julia, Rose, Bernd Oliver, Reece-Anthony, Rosie, Ryan, Christine, Hamilton, Mark, Hopkins, Philip, Wendon, Julia, Brescia, Giovanni, Ijaz, Nazia, Wood, James, George, Michelle, Toth-Tarsoly, Piroska, Yates, Bryan, Armstrong, Maureen, Scott, Carmen, Boyd, Christine, Szakmany, Tamas ORCID: https://orcid.org/0000-0003-3632-8844, Rees, David, Pulak, Paul, Coggon, Mandy, Saha, Bhaskar, Kent, Linda, Gibson, Bethan, Camsooksai, Julie, Reschreiter, Henrik, Morgan, Pat, Sangaralingham, Sivatharshini, Lowe, Alastair, Vondras, Petr, Jamadarkhana, Sunil, Cruz, Carina, Bhandary, Rakesh, Hersey, Peter, Furneval, Julie, Innes, Richard, Doble, Patricia, Attwood, Ben, Parsons, Penny, Page, Valerie, Zhao, Xiaobei, Dalton, Julian, Hegazy, Mohammed, Awad, Yasser, Naylor, Douglas, Naylor, Amanda, Lee, Sarah, Brevard, Sidney and Davis, Noelle 2019. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: 'AbSeS', a multinational observational cohort study and ESICM trials croup project. Intensive Care Medicine 45 (12) , pp. 1703-1717. 10.1007/s00134-019-05819-3

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Abstract

Purpose To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer Verlag (Germany)
ISSN: 0342-4642
Date of First Compliant Deposit: 18 September 2020
Date of Acceptance: 9 October 2019
Last Modified: 17 May 2023 07:03
URI: https://orca.cardiff.ac.uk/id/eprint/134913

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