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In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches

Kukharsky, Michail S., Skvortsova, Veronika I., Bachurin, Sergey O. and Buchman, Vladimir L. 2020. In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches. Medicinal Research Reviews 10.1002/med.21725
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Abstract

Recent progress in understanding the pathological changes in the nervous system and in certain other body systems (e.g., immune system) that lead to the development and progression of amyotrophic lateral sclerosis (ALS) revealed a number of molecular and cellular processes that can potentially be used as therapeutic targets. Many of these processes are compromised not only in ALS but also in other diseases and a repertoire of drugs able to restore, at least partially, their functionality has been developed. In this review, we briefly describe current approaches to the repurposing of such “old” drugs for treatment of patients with ALS.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Biosciences
Publisher: Wiley
ISSN: 0198-6325
Date of First Compliant Deposit: 21 September 2020
Date of Acceptance: 8 August 2020
Last Modified: 28 Nov 2020 20:33
URI: http://orca.cf.ac.uk/id/eprint/134969

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