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Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration

Lawrence, Elizabeth A., Hammond, Chrissy L. and Blain, Emma J. 2020. Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration. Histochemistry and Cell Biology 154 , pp. 521-531. 10.1007/s00418-020-01918-1

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Abstract

Mechanically mediated joint degeneration and cartilage dyshomeostasis is implicated in highly prevalent diseases such as osteoarthritis. Increasingly, MicroRNAs are being associated with maintaining the normal state of cartilage, making them an exciting and potentially key contributor to joint health and disease onset. Here, we present a summary of current in vitro and in vivo models which can be used to study the role of mechanical load and MicroRNAs in joint degeneration, including: non-invasive murine models of PTOA, surgical models which involve ligament transection, and unloading models based around immobilisation of joints or removal of load from the joint through suspension. We also discuss how zebrafish could be used to advance this field, namely through the availability of transgenic lines relevant to cartilage homeostasis and the ability to accurately map strain through the cartilage, enabling the response of downstream MicroRNA targets to be followed dynamically at a cellular level in areas of high and low strain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer Verlag (Germany)
ISSN: 0948-6143
Date of First Compliant Deposit: 24 September 2020
Date of Acceptance: 31 August 2020
Last Modified: 25 Nov 2020 11:08
URI: http://orca.cf.ac.uk/id/eprint/135067

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