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Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Schirmer, Lucas, Hoornaert, Chloé, Le Blon, Debbie, Eigel, Dimitri, Neto, Catia, Gumbleton, Mark, Welzel, Petra B., Rosser, Anne E., Werner, Carsten, Ponsaerts, Peter and Newland, Ben 2020. Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain. Biomaterials Science 8 (18) , pp. 4997-5004. 10.1039/D0BM01249A

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Abstract

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
Publisher: Royal Society of Chemistry
ISSN: 2047-4830
Funders: Wellcome Trust
Date of First Compliant Deposit: 28 September 2020
Date of Acceptance: 1 September 2020
Last Modified: 26 Oct 2020 15:18
URI: http://orca.cf.ac.uk/id/eprint/135174

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