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Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus, Akber, Mira, Berglin, Lena, Bergsten, Helena, Brighenti, Susanna, Brownlie, Demi, Butrym, Marta, Chambers, Benedict, Chen, Puran, Jeannin, Martin Cornillet, Grip, Jonathan, Gomez, Angelica Cuapio, Dillner, Lena, Lozano, Isabel Diaz, Dzidic, Majda, Tullberg, Malin Flodström, Färnert, Anna, Glans, Hedvig, Haroun-Izquierdo, Alvaro, Henriksson, Elizabeth, Hertwig, Laura, Kalsum, Sadaf, Kokkinou, Efthymia, Kvedaraite, Egle, Loreti, Marco, Lourda, Magalini, Maleki, Kimia, Malmberg, Karl-Johan, Marquardt, Nicole, Maucourant, Christopher, Michaelsson, Jakob, Mjösberg, Jenny, Moll, Kirsten, Muva, Jagadees, Mårtensson, Johan, Nauclér, Pontus, Norrby-Teglund, Anna, Medina, Laura Palma, Persson, Björn, Radler, Lena, Ringqvist, Emma, Sandberg, John Tyler, Sohlberg, Ebba, Soini, Tea, Svensson, Mattias, Tynell, Janne, Varnaite, Renata, Kries, Andreas Von and Unge, Christian 2020. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. Cell 183 (1) , pp. 158-168. 10.1016/j.cell.2020.08.017

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Abstract

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier (Cell Press)
ISSN: 0092-8674
Date of First Compliant Deposit: 14 October 2020
Date of Acceptance: 11 August 2020
Last Modified: 06 May 2023 07:21
URI: https://orca.cardiff.ac.uk/id/eprint/135583

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