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Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

Gridchyn, Igor, Schoenenberger, Philipp, O'Neill, Joseph and Csicsvari, Jozsef 2020. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. eLife 2020 (9) , e61106. 10.7554/eLife.61106

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Abstract

In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity. Both behavioral and learning-dependent reorganization of these connections has also been demonstrated by measuring spike transmission probabilities in pyramidal cell-interneuron spike cross-correlations that indicate monosynaptic connections. Here we investigated the activity-dependent modification of these connections during exploratory behavior in rats by optogenetically inhibiting pyramidal cell and interneuron subpopulations. Light application and associated firing alteration of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron connection weights as indicated by spike transmission changes. Spike transmission alterations were predicted by the light-mediated changes in the number of pre- and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal cells. This work demonstrates the presence of activity-dependent associative and non-associative reorganization of pyramidal-interneuron connections triggered by the optogenetic modification of the firing rate and spike synchrony of cells.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Psychology
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Date of First Compliant Deposit: 26 October 2020
Date of Acceptance: 5 October 2020
Last Modified: 26 Oct 2020 17:00
URI: http://orca.cf.ac.uk/id/eprint/135943

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