Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Genotyping of methicillin resistant Staphylococcus aureus from the United Arab Emirates

Senok, Abiola, Nassar, Rania, Celiloglu, Handan, Nabi, Anju, Alfaresi, Mubarak, Weber, Stefan, Rizvi, Irfan, Muller, Elke, Reissig, Annett, Gawlik, Darius, Monecke, Stefan and Ehricht, Ralf 2020. Genotyping of methicillin resistant Staphylococcus aureus from the United Arab Emirates. Scientific Reports 10 , 18551. 10.1038/s41598-020-75565-w

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (916kB)
[img] PDF - Supplemental Material
Available under License Creative Commons Attribution.

Download (73kB)


Reports from Arabian Gulf countries have demonstrated emergence of novel methicillin resistant Staphylococcus aureus (MRSA) strains. To address the lack of data from the United Arab Emirates (UAE), genetic characterisation of MRSA identified between December 2017 and August 2019 was conducted using DNA microarray-based assays. The 625 MRSA isolates studied were grouped into 23 clonal complexes (CCs) and assigned to 103 strains. CC5, CC6, CC22 and CC30 represented 54.2% (n/N = 339/625) of isolates with other common CCs being CC1, CC8, CC772, CC361, CC80, CC88. Emergence of CC398 MRSA, CC5-MRSA-IV Sri Lanka Clone and ST5/ST225-MRSA-II, Rhine-Hesse EMRSA/New York-Japan Clone in our setting was detected. Variants of pandemic CC8-MRSA-[IVa + ACME I] (PVL+) USA300 were detected and majority of CC772 strains were CC772-MRSA-V (PVL+), “Bengal- Bay Clone”. Novel MRSA strains identified include CC5-MRSA-V (edinA+), CC5-MRSA-[VT + fusC], CC5-MRSA-IVa (tst1+), CC5-MRSA-[V/VT + cas + fusC + ccrA/B-1], CC8-MRSA-V/VT, CC22-MRSA-[IV + fusC + ccrAA/(C)], CC45-MRSA-[IV + fusC + tir], CC80-MRSA-IVa, CC121-MRSA-V/VT, CC152-MRSA-[V + fusC] (PVL+). Although several strains harboured SCC-borne fusidic acid resistance (fusC) (n = 181), erythromycin/clindamycin resistance (ermC) (n = 132) and gentamicin resistance (aacA-aphD) (n = 179) genes, none harboured vancomycin resistance genes while mupirocin resistance gene mupR (n = 2) and cfr gene (n = 1) were rare. An extensive MRSA repertoire including CCs previously unreported in the region and novel strains which probably arose locally suggest an evolving MRSA landscape.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Publisher: Nature Publishing Group
ISSN: 2045-2322
Date of First Compliant Deposit: 9 November 2020
Date of Acceptance: 16 November 2020
Last Modified: 09 Nov 2020 16:16

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics