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The dual role of high endothelial venules in cancer progression versus immunity

Milutinovic, Stefan, Abe, Jun, Godkin, Andrew, Stein, Jens V. and Gallimore, Awen 2021. The dual role of high endothelial venules in cancer progression versus immunity. Trends in Cancer 7 (3) , pp. 214-225. 10.1016/j.trecan.2020.10.001

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Secondary lymphoid organs (SLOs) are important initiators and regulators of immunity. To carry out this function, the blood vasculature must deliver oxygen and nutrients and recruit circulating lymphocytes into the SLO parenchyma, where they encounter cognate antigen. High endothelial venules (HEVs) are specialised postcapillary venules that specifically serve this function and are found in all SLOs except spleen. It is becoming clear that alterations to HEV network density and/or morphology can result in immune activation or, as recently implicated, in providing an exit route for tumour cell dissemination and metastases. In this review, the structural plasticity of HEVs, the regulatory pathways underpinning this plasticity, and the relevance of these pathways to cancer progression will be discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Cell Press
ISSN: 2405-8033
Funders: Cancer Research UK
Date of First Compliant Deposit: 11 November 2020
Date of Acceptance: 6 October 2020
Last Modified: 09 Mar 2021 12:58

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