Expedient organocatalytic Aza-Morita–Baylis–Hillman reaction through ball-milling

Williams, Matthew T. J., Morrill, Louis C. and Browne, Duncan L. 2020. Expedient organocatalytic Aza-Morita–Baylis–Hillman reaction through ball-milling. ACS Sustainable Chemistry and Engineering 8 (48) , pp. 17876-17881. 10.1021/acssuschemeng.0c07320

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Abstract

A ball-milling enabled tertiary amine catalyzed aza-Morita–Baylis–Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	2168-0485
Funders:	EPSRC
Date of First Compliant Deposit:	3 December 2020
Date of Acceptance:	9 November 2020
Last Modified:	14 Jan 2021 09:33
URI:	http://orca.cf.ac.uk/id/eprint/136753

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