Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Prostate cancer undetected by mpMRI: tumor conspicuity is reliant upon optimal scan timing and quality

Norris, Joseph M., Allen, Clare, Ball, Rhys, Freeman, Alex, Giganti, Francesco, Kelly, Daniel, Kirkham, Alex, Simpson, Benjamin S., Stavrinides, Vasilis, Whitaker, Hayley C. and Emberton, Mark 2020. Prostate cancer undetected by mpMRI: tumor conspicuity is reliant upon optimal scan timing and quality. Urology 10.1016/j.urology.2020.11.037

Full text not available from this repository.

Abstract

We commend Alanee et al for their detailed description of prostate cancers not detected by multiparametric magnetic resonance imaging (mpMRI). 1 They analyzed radical prostatectomy findings for 33 men lacking mpMRI-conspicuous prostate cancer (defined as Prostate Imaging Reporting and Data System [PI-RADS] scores 1-2) on preoperative mpMRI. They found 27% (9/33) of men with negative mpMRI had Gleason Grade Group (GGG) 3-5 cancer at prostatectomy, including 9 with extraprostatic extension, and 1 with Gleason grade 5 + 5 disease. Ostensibly, these findings are at odds with contemporary evidence in which mpMRI-invisible disease harbors reassuring molecular and histopathological features (ie, overall GGG ≤2). 2 , 3 We believe that this discrepancy is attributable to certain methodological concerns, including quality of mpMRI acquisiton. 4

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Healthcare Sciences
Publisher: Elsevier
ISSN: 0090-4295
Last Modified: 08 Dec 2020 11:00
URI: http://orca.cf.ac.uk/id/eprint/136839

Actions (repository staff only)

Edit Item Edit Item