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Treating secondary antibody deficiency in patients with haematological malignancy: European expert consensus

Jolles, Stephen, Michallet, Mauricette, Agostini, Carlo, Albert, Michael H., Edgar, David, Ria, Roberto, Trentin, Livio and Lévy, Vincent 2021. Treating secondary antibody deficiency in patients with haematological malignancy: European expert consensus. European Journal of Haematology 10.1111/ejh.13580
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Objectives Secondary antibody deficiency (SAD), associated with severe, recurrent or persistent infections, is common in patients with haematological malignancies (HM), but unifying guidance on immunoglobulin replacement therapy (IgRT) in these patients is lacking. We aimed to develop consensus statements for the use of IgRT in patients with HM. Methods A Delphi exercise was employed to test the level of agreement on statements developed by a Task Force based on available data and their clinical experience. In Round 1, an Expert Panel, comprising specialist EU physicians caring for patients with HM, helped to refine the statements. In Round 2, experts rated their agreement with the statements. In Round 3, experts who had scored their agreement as ≤4 were invited to review their agreement based on the overall feedback. Results Three definitions and 20 statements were formulated and tested for consensus, covering measurement of IgG levels, initiation and discontinuation of IgRT, dosing, and the use of subcutaneous IgG. Consensus (agreement ≥70% on Likert‐type scale) was reached for all three definitions and 18 statements. Conclusions Recommendations have been developed with the aim of providing guidance for the use of IgRT to prevent severe, recurrent or persistent infections in patients with HM and SAD.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Publisher: Wiley
ISSN: 0902-4441
Funders: N/A
Date of First Compliant Deposit: 19 January 2021
Date of Acceptance: 12 January 2021
Last Modified: 20 Jan 2021 02:20

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