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Genomic imprinting effects on brain development and function

Wilkinson, Lawrence Stephen, Davies, William and Isles, Anthony Roger 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11) , pp. 832-843. 10.1038/nrn2235

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Abstract

In a small fraction of mammalian genes — at present estimated at less than 1% of the total — one of the two alleles that is inherited by the offspring is partially or completely switched off. The decision as to which one is silenced depends on which allele was inherited from the mother and which from the father. These idiosyncratic loci are known as imprinted genes, and their existence is an evolutionary enigma, as they effectively nullify the advantages of diploidy. Although they are small in number, these genes have important effects on physiology and behaviour, and many are expressed in the brain. There is increasing evidence that imprinted genes influence brain function and behaviour by affecting neurodevelopmental processes.

Item Type: Article
Status: Published
Schools: Psychology
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1471-003X
Last Modified: 24 Apr 2019 13:47
URI: http://orca.cf.ac.uk/id/eprint/13779

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