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The variability of MR axon radii estimates in the human white matter

Veraart, Jelle, Raven, Erika P., Edwards, Luke J., Weiskopf, Nikolaus and Jones, Derek K. 2021. The variability of MR axon radii estimates in the human white matter. Human Brain Mapping 10.1002/hbm.25359

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Abstract

The noninvasive quantification of axonal morphology is an exciting avenue for gaining understanding of the function and structure of the central nervous system. Accurate non‐invasive mapping of micron‐sized axon radii using commonly applied neuroimaging techniques, that is, diffusion‐weighted MRI, has been bolstered by recent hardware developments, specifically MR gradient design. Here the whole brain characterization of the effective MR axon radius is presented and the inter‐ and intra‐scanner test–retest repeatability and reproducibility are evaluated to promote the further development of the effective MR axon radius as a neuroimaging biomarker. A coefficient‐of‐variability of approximately 10% in the voxelwise estimation of the effective MR radius is observed in the test–retest analysis, but it is shown that the performance can be improved fourfold using a customized along‐tract analysis.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Wiley
ISSN: 1065-9471
Funders: Wellcome Trust
Date of First Compliant Deposit: 25 January 2021
Date of Acceptance: 21 January 2021
Last Modified: 18 Mar 2021 13:23
URI: http://orca.cf.ac.uk/id/eprint/137929

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