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Common and rare DPYD variants are predictive for 5FU/capecitabine (5FU) toxicity: The MRC COIN and COIN-B trials

Madi, A., Fisher, D., Maughan, T. S., Colley, J. P., Meade, A. M., Maynard, J., Humphreys, V., Wasan, H., Adams, R. A., Idziaszczyk, S., Harris, R., Kaplan, R. S. and Cheadle, J. P. 2018. Common and rare DPYD variants are predictive for 5FU/capecitabine (5FU) toxicity: The MRC COIN and COIN-B trials. Presented at: 43rd ESMO Congress 2018, Munich, Germany, 19-23 October 2018. , vol. Supple. Oxford University Press, VIII22. 10.1093/annonc/mdy269.072

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Abstract

Rare genetic variants in DPYP increase toxicity and screening for them prevents serious complications by upfront reduction in 5FU dose; however, most patients with severe toxicities do not have a rare mutation. We have previously shown that 2 common DPYD variants were associated with toxicity in patients with advanced colorectal cancer treated on COIN & COIN-B (abstract 3509, ASCO 2013): Cys29Arg [rs1801265] (Minor Allele Frequency (MAF) 0.21) and Val732Ile [rs1801160] (MAF 0.04). We have now genotyped 4 rare variants using the same cohort.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Oxford University Press
ISSN: 0923-7534
Last Modified: 08 Feb 2021 14:30
URI: http://orca.cf.ac.uk/id/eprint/138302

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