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Macrophage reprogramming for therapy

Bart, Valentina M. T., Pickering, Robert J., Taylor, Philip R. and Ipseiz, Natacha 2020. Macrophage reprogramming for therapy. Immunology 10.1111/imm.13300

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Abstract

Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent cutting‐edge technologies have highlighted macrophages as potential targets for disease control. Macrophages play central roles in development, homeostasis and host defence, and their dysfunction and dysregulation have been implicated in the onset and pathogenesis of multiple disorders including cancer, neurodegeneration, autoimmunity and metabolic diseases. Recent advancements have led to a greater understanding of macrophage origin, diversity and function, in both health and disease. Over the last few years, a variety of strategies targeting macrophages have been developed and these open new therapeutic opportunities. Here, we review the progress in macrophage reprogramming in various disorders and discuss the potential implications and challenges for macrophage‐targeted approaches in human disease.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License
Publisher: Wiley
ISSN: 0019-2805
Funders: Wellcome Trust
Date of First Compliant Deposit: 10 February 2021
Date of Acceptance: 11 December 2020
Last Modified: 18 Mar 2021 11:37
URI: http://orca.cf.ac.uk/id/eprint/138440

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