Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

An interactive meta-analysis of MRI biomarkers of myelin.

Macini, Matteo, Karakuzu, Agah, Cohen-Adad, Julien, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456, Nichols, Thomas E. and Stikov, Nikola 2020. An interactive meta-analysis of MRI biomarkers of myelin. eLife 2020 (9) , e61523. 10.7554/elife.61523

[thumbnail of elife-61523-v2.pdf] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of discussion. Debate about which MRI measure is the most suitable for quantifying myelin is still ongoing. In this study, we performed a systematic review of published quantitative validation studies to clarify how different these measures are when compared to the underlying histology. We analyzed the results from 43 studies applying meta-analysis tools, controlling for study sample size and using interactive visualization (https://neurolibre.github.io/myelin-meta-analysis). We report the overall estimates and the prediction intervals for the coefficient of determination and find that MT and relaxometry-based measures exhibit the highest correlations with myelin content. We also show which measures are, and which measures are not statistically different regarding their relationship with histology.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Date of First Compliant Deposit: 10 March 2021
Date of Acceptance: 20 October 2020
Last Modified: 05 May 2023 07:32
URI: https://orca.cardiff.ac.uk/id/eprint/139589

Citation Data

Cited 53 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics