Editorial: The complexity of primary antibody deficiencies

Quinti, Isabella, Spadaro, Giuseppe, Jolles, Stephen and Condino-Neto, Antonio 2021. Editorial: The complexity of primary antibody deficiencies. Frontiers in Immunology 12 , 635482. 10.3389/fimmu.2021.635482

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Abstract

Primary antibody deficiencies represent by far the largest group of primary immunodeficiencies (PID) at 56% (ESID Registry), however the proportion of patients in whom antibody deficiency represents a component of their condition is greater still at around 75% (1). It has become clear over recent years that while the vast majority of such patients experience recurrent infections a significant proportion are also affected by non-infectious dysregulatory complications which include malignancy, autoimmunity, inflammation and allergy (Figure 1). The increasingly complex manifestations of Primary Antibody Deficiencies have a major impact on the clinical management of patients and raise diagnostic and therapeutic challenges (2). This Research Topic draws together a series of reports focusing on a range of these non-infectious complications and their clinical implications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Frontiers Media
ISSN:	1664-3224
Funders:	N/A
Date of First Compliant Deposit:	17 May 2021
Date of Acceptance:	12 March 2021
Last Modified:	06 May 2023 04:48
URI:	https://orca.cardiff.ac.uk/id/eprint/141315

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