Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

On-resin Passerini reaction toward C-terminal photocaged peptides

So, Wing Ho and Xia, Jiang 2020. On-resin Passerini reaction toward C-terminal photocaged peptides. Organic Letters 22 (1) , pp. 214-218. 10.1021/acs.orglett.9b04182

Full text not available from this repository.

Abstract

An on-resin, three-component Passerini reaction was developed to synthesize C-terminal photocaged peptides. Highly compatible with conventional Fmoc SPPS, this reaction produces peptides with a C-terminal o-amido-6-nitroveratryl (αANV) ester in one pot with conserved chirality. Under physiological conditions, the C-terminal αANV ester rapidly photolyzed to revert to carboxylate, offering a convenient method for optical control of cellular signals by modulating the C-terminal carboxylate.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 27 Sep 2022 01:06
URI: https://orca.cardiff.ac.uk/id/eprint/141496

Citation Data

Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item