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Hepatocyte growth factor modulates vascular endothelial-cadherin expresssion in human endothelial cells

Martin, Tracey Amanda, Mansel, Robert Edward and Jiang, Wen Guo 2001. Hepatocyte growth factor modulates vascular endothelial-cadherin expresssion in human endothelial cells. Clinical Cancer Research 7 (3) , pp. 734-737.

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Abstract

Hepatocyte growth factor (HGF)/scatter factor (SF) is a cytokine exerting a wide range of biological functions on many cell types, including vascular endothelial cells. HGF/SF increases migration, motility, and dissociation of human umbilical vascular endothelial cells (HUVECs). This study demonstrated that such action of HGF/SF on HUVECs was achieved by regulation of the endothelial cell-specific cadherin, vascular endothelial (VE)-cadherin. HGF/SF induced a time-dependent reduction of VE-cadherin protein from HUVECs as shown by Western blotting and immunocytochemistry, accompanied by an increase in the migration of HUVECs. The change of VE-cadherin appeared at the mRNA level, as demonstrated by reverse transcription-PCR, with a decrease in the VE-cadherin signal. These results show, for the first time, that HGF/SF targets the endothelial cell-specific adhesion molecule VE-cadherin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Association for Cancer Research
ISSN: 1078-0432
Last Modified: 04 Jun 2017 01:30
URI: http://orca.cf.ac.uk/id/eprint/144

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