Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity

Gully, Benjamin S., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Davey, Martin S. 2021. Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity. Biochemical Society Transactions 10.1042/BST20200890

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Abstract

The γδ T cell immune cell lineage has remained relatively enigmatic and under-characterised since their identification. Conversely, the insights we have, highlight their central importance in diverse immunological roles and homeostasis. Thus, γδ T cells are considered as potentially a new translational tool in the design of new therapeutics for cancer and infectious disease. Here we review our current understanding of γδ T cell biology viewed through a structural lens centred on the how the γδ T cell receptor mediates ligand recognition. We discuss the limited knowledge of antigens, the structural basis of such reactivities and discuss the emerging trends of γδ T cell reactivity and implications for γδ T cell biology.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY)
Publisher:	Portland Press
ISSN:	0300-5127
Date of First Compliant Deposit:	7 October 2021
Date of Acceptance:	19 August 2021
Last Modified:	18 May 2023 19:14
URI:	https://orca.cardiff.ac.uk/id/eprint/144725

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