Miller, David James and Allemann, Rudolf Konrad 2012. Sesquiterpene synthases: Passive catalysts or active players? Natural Product Reports 29 (1) , pp. 60-71. 10.1039/c1np00060h |
Abstract
Sesquiterpene synthases catalyse the metal dependent turnover of farnesyl diphosphate to generate a class of natural products characterised by an enormous diversity in structure, stereochemistry, biological function and application. It has been proposed that these enzymes take a passive role in the reactions they catalyse and that they serve mostly as stereochemical templates, within which the reactions take place. Here, recent research into the structure and function of sesquiterpene synthases and the mechanisms of the reactions that they catalyse will be reviewed to suggest that these fascinating enzymes play multifaceted active roles in what are arguably the most complex biosynthetic reactions.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Cardiff Catalysis Institute (CCI) Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | Royal Society of Chemistry |
ISSN: | 0265-0568 |
Funders: | BBSRC, EPSRC |
Last Modified: | 04 Jun 2017 02:57 |
URI: | http://orca.cf.ac.uk/id/eprint/14511 |
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