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Prediction of the frictional behavior of mammalian tissues against biomaterials

Prokopovich, Polina and Perni, S. 2010. Prediction of the frictional behavior of mammalian tissues against biomaterials. Acta Biomaterialia 6 (10) , pp. 4052-4059. 10.1016/j.actbio.2010.05.007

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Abstract

Frictional and adhesion properties are important characteristics to be assessed in the development of new materials for biological applications, particularly for medical devices such as catheters. In this work a new computational method that predicts frictional and adhesive forces is presented. A multi-asperities adhesion model, based on the JKR theory, coupled with a Monte Carlo method was employed, together with a three components friction model. This takes into account interfacial adhesion, asperities deformation and viscous lubricant film shearing action. We have estimated the frictional coefficients of silicone and polyurethane (common materials in catheters) against aorta and vena cava. In order to do this, we have measured the surface properties of the two blood vessels tissues, such as surface energy components, asperity height distribution and asperity radius of curvature. These data have not been previously reported. The predictions in both the dry and in lubricated (with blood) cases are in very good agreement with our published experimental data of the same materials/tissue combinations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Blood vessels; Adhesion; Biomaterials; Catheters; Friction
Publisher: Elsevier
ISSN: 1742-7061
Last Modified: 10 Nov 2017 13:53
URI: http://orca.cf.ac.uk/id/eprint/14680

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Cited 9 times in Web of Science. View in Web of Science.

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