Leukocyte trafficking in cardiovascular disease: insights from experimental models

Jones, Daniel P., True, Harry D. and Patel, Jyoti 2017. Leukocyte trafficking in cardiovascular disease: insights from experimental models. Mediators of Inflammation 2017 , 9746169. 10.1155/2017/9746169

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Abstract

Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License
Publisher:	Hindawi Publishing Corporation
ISSN:	0962-9351
Date of First Compliant Deposit:	19 May 2022
Last Modified:	07 May 2023 09:06
URI:	https://orca.cardiff.ac.uk/id/eprint/148456

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