Macromolecular background signal and non‐Gaussian metabolite diffusion determined in human brain using ultra‐high diffusion weighting

Şimşek, Kadir, Döring, André, Pampel, André, Möller, Harald E. and Kreis, Roland 2022. Macromolecular background signal and non‐Gaussian metabolite diffusion determined in human brain using ultra‐high diffusion weighting. Magnetic Resonance in Medicine 88 (5) , pp. 1962-1977. 10.1002/mrm.29367

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Abstract

Purpose: Definition of a macromolecular MR spectrum based on diffusion properties rather than relaxation time differences and characterization of non‐Gaussian diffusion of brain metabolites with strongly diffusion‐weighted MR spectroscopy. Methods: Short echo time MRS with strong diffusion‐weighting with b‐values up to 25 ms/μm2 at two diffusion times was implemented on a Connectom system and applied in combination with simultaneous spectral and diffusion decay modeling. Motion‐compensation was performed with a combined method based on the simultaneously acquired water and a macromolecular signal. Results: The motion compensation scheme prevented spurious signal decay reflected in very small apparent diffusion constants for macromolecular signal. Macromolecular background signal patterns were determined using multiple fit strategies. Signal decay corresponding to non‐Gaussian metabolite diffusion was represented by biexponential fit models yielding parameter estimates for human gray matter that are in line with published rodent data. The optimal fit strategies used constraints for the signal decay of metabolites with limited signal contributions to the overall spectrum. Conclusion: The determined macromolecular spectrum based on diffusion properties deviates from the conventional one derived from longitudinal relaxation time differences calling for further investigation before use as experimental basis spectrum when fitting clinical MR spectra. The biexponential characterization of metabolite signal decay is the basis for investigations into pathologic alterations of microstructure.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc/4.0/
Publisher:	Wiley
ISSN:	0740-3194
Date of First Compliant Deposit:	11 July 2022
Date of Acceptance:	31 May 2022
Last Modified:	14 May 2023 11:09
URI:	https://orca.cardiff.ac.uk/id/eprint/151230

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