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Evolutionary and biomedical insights from the rhesus macaque genome

Gibbs, Richard. A., Rogers, Jeffrey, Katz, Michael G., Ball, Edward Vincent, Cooper, David Neil, Stenson, Peter Daniel and Zweig, Ann S. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316 (5822) , pp. 222-34. 10.1126/science.1139247

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Abstract

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
ISSN: 1095-9203
Last Modified: 04 Jun 2017 01:30
URI: http://orca.cf.ac.uk/id/eprint/153

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