| Broadley, Kenneth John, Davies, Robin H., Escargueil, Christine, Lee, Alan T. L., Penson, Peter Edward and Thomas, Eric J. 2011. Synthesis of antagonists of muscarinic (M3) receptors. Collection Of Czechoslovak Chemical Communications 76 (7) , pp. 781-801. 10.1135/cccc2011017 |
Official URL: http://dx.doi.org/10.1135/cccc2011017
Abstract
Several α-hydroxyamides with (2,6-dialkoxyphenoxy)methyl substituents have been prepared and their activities as antagonists of the M3 muscarinic receptor in guinea pig ileum have been evaluated. N-{1-[(Phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-dimethoxyphenoxy)-methyl]phenyl}-2-hydroxypropanamide and N-(1-[{6-amino-4-[(1-propylpiperidin-4-yl)methyl]pyridin-2-yl}methyl]piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide were the most potent compounds prepared, the micromolar potency of the latter indicating that it may be worth further investigation.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Pharmacy |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Uncontrolled Keywords: | Muscarinic receptors; Antagonists; Suzuki–Miyaura coupling; α-Hydroxyamides; Alcohols; Amides; Biological activity; Medicinal chemistry |
| Additional Information: | Effective January 1, 2012, the journal is published under the name ChemPlusChem by Wiley-VCH. |
| Publisher: | Institute of Organic Chemistry and Biochemistry |
| ISSN: | 0010-0765 |
| Related URLs: | |
| Last Modified: | 05 Jan 2018 20:57 |
| URI: | http://orca.cf.ac.uk/id/eprint/15436 |
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