Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering

Doyle, Michael Eugene, Dalgarno, Kenny, Masoero, Enrico and Ferreira, Ana Marina 2023. Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering. Biopolymers 114 , e23527. 10.1002/bip.23527

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Abstract

With an ageing world population and ~20% of adults in Europe being affected by bone diseases, there is an urgent need to develop advanced regenerative approaches and biomaterials capable to facilitate tissue regeneration while providing an adequate microenvironment for cells to thrive. As the main components of bone are collagen and apatite mineral, scientists in the tissue engineering field have attempted in combining these materials by using different biomimetic approaches to favour bone repair. Still, an ideal bone analogue capable of mimicking the distinct properties (i.e., mechanical properties, degradation rate, porosity, etc.) of cancellous bone is to be developed. This review seeks to sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher:	Wiley
ISSN:	0006-3525
Date of First Compliant Deposit:	30 November 2022
Date of Acceptance:	11 November 2022
Last Modified:	06 Jan 2024 02:11
URI:	https://orca.cardiff.ac.uk/id/eprint/154569

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