Comparative anti-microbial efficacy of Azadirachta indica irrigant with standard endodontic irrigants: a preliminary study

Dutta, Arindam ORCID: https://orcid.org/0000-0003-4488-0831 and Kundabala, Mala 2014. Comparative anti-microbial efficacy of Azadirachta indica irrigant with standard endodontic irrigants: a preliminary study. Journal of Conservative Dentistry 17 (2) , pp. 133-137. 10.4103/0972-0707.128047

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Abstract

Objective: The anti-microbial efficacy of 2.5% sodium hypochlorite (SHC) and 0.2% chlorhexidine gluconate were compared with an experimental irrigant formulated from the Neem tree, Azadirachta indica A. Juss. Materials and Methods: A sample of 36 single rooted anterior teeth with periapical radiolucency and absence of response to vitality tests that required root canal treatment were selected for this study. The test irrigants and their combinations were assigned to five different groups and saline served as the control. Access cavities were prepared using an aseptic technique and samples collected for both anaerobic culture and Gram stained smears, followed by irrigation and sample collection again. The number of organisms were expressed in colony forming units/ml after 72 h of incubation; the smears were analyzed for their microbial loads and tissue clearance and assessed as per defined criteria. Results: Our results found the maximum reduction in microbial loads, when analyzed by culture method, with a combination of SHC and the experimental neem irrigant. Maximum tissue clearance on the Gram Stained smears was also found with the same combination. Conclusion: Neem irrigant has anti-microbial efficacy and can be considered for endodontic use.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Dentistry
Publisher:	Medknow Publications
ISSN:	0972-0707
Date of Acceptance:	7 January 2014
Last Modified:	24 Jan 2023 10:45
URI:	https://orca.cardiff.ac.uk/id/eprint/155862

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