The top 10 research priorities in psoriatic arthritis: a James Lind alliance priority setting partnership

Hailey, Louise, Bundy, Chris ORCID: https://orcid.org/0000-0002-5981-3984, Burstow, Helen, Chandler, David, Cowper, Russ, Helliwell, Philip, Joannes, Lucille, Kelly, Andy, Kennedy, Bronagh, Kinsella, Suzannah, McAteer, Helen, Mukherjee, Sandeep, Packham, Jon, Wise, Elspeth, Young, Helen and Coates, Laura C. 2023. The top 10 research priorities in psoriatic arthritis: a James Lind alliance priority setting partnership. Rheumatology 62 (8) , pp. 2716-2723. 10.1093/rheumatology/keac676

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Abstract

Objectives To identify and prioritize the top 10 research questions for PsA. Methods The British Psoriatic Arthritis Consortium (BritPACT) formed a Priority Setting Partnership (PSP) comprising of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP followed the established three-stage JLA process: first, an online survey of people living with PsA, carers and clinicians to identify PsA questions, asking, ‘What do you think are the most important unanswered questions in psoriatic arthritis research?’ The questions were checked against existing evidence to establish ‘true uncertainties’ and grouped as ‘indicative questions’ reflecting the overarching themes. Then a second online survey ranked the ‘true uncertainties’ by importance. Finally, a workshop including people living with PsA and clinician stakeholders finalized the top 10 research priorities. Results The initial survey attracted 317 respondents (69% people living with PsA, 15% carers), with 988 questions. This generated 46 indicative questions. In the second survey, 422 respondents (78% people living with PsA, 4% carers) prioritized these. Eighteen questions were taken forward to the final online workshop. The top unanswered PsA research question was ‘What is the best strategy for managing patients with psoriatic arthritis including non-drug and drug treatments?’ Other top 10 priorities covered diagnosis, prognosis, outcome assessment, flares, comorbidities and other aspects of treatment (https://www.jla.nihr.ac.uk). Conclusion The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	Oxford University Press
ISSN:	1462-0324
Date of First Compliant Deposit:	3 February 2023
Date of Acceptance:	23 November 2022
Last Modified:	28 Sep 2023 03:52
URI:	https://orca.cardiff.ac.uk/id/eprint/156488

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