World workshop on oral medicine VIII: Development of a core outcome set for dry mouth: A systematic review of outcome domains for salivary hypofunction

Simms, Melanie L., Kuten-Shorrer, Michal, Wiriyakijja, Paswach, Niklander, Sven E., Santos-Silva, Alan R., Sankar, Vidya, Kerr, Alexander R., Jensen, Siri B., Riordain, Richeal N., Delli, Konstantina and Villa, Alessandro 2023. World workshop on oral medicine VIII: Development of a core outcome set for dry mouth: A systematic review of outcome domains for salivary hypofunction. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 135 (6) , pp. 804-826. 10.1016/j.oooo.2022.12.018

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Abstract

Objective To identify all outcome measures used to assess salivary gland hypofunction (i.e.: objective measures used to determine actual changes in saliva quantity or to assess response to treatment of salivary gland hypofunction) and to group these into domains. Study Design A systematic review including clinical trials, and prospective or retrospective observational studies involving human participants with dry mouth, with any type of intervention where objective assessment of salivary gland hypofunction was described. Results Five hundred fifty-three studies involving 31,507 participants were identified. The majority assessed both salivary gland hypofunction and xerostomia (68.7%), whilst 31.3% assessed salivary gland hypofunction alone. The majority of studies investigated ‘amount of saliva’ and the highest number of outcome measures was within the domain ‘clinical/objective signs of salivary gland hypofunction’. Conclusions Seven domains encompassing 30 outcome measures were identified, confirming the diversity in outcomes and outcome measures used in research regarding salivary gland hypofunction. Identified items will be used in conjunction with those identified regarding xerostomia to create a COS for dry mouth quantification for use in future clinical trials, with the overall goal of improving the standardization of reporting, leading to the establishment of more robust evidence for the management of dry mouth and improving patient care.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Elsevier
ISSN:	2212-4403
Date of First Compliant Deposit:	9 March 2023
Date of Acceptance:	15 December 2022
Last Modified:	02 Mar 2024 16:21
URI:	https://orca.cardiff.ac.uk/id/eprint/157617

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