Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice

Bryson, K. J., Wei, Xiao-Qing and Alexander, J. 2008. Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice. Microbes and Infection 10 (7) , pp. 834-839. 10.1016/j.micinf.2008.03.009

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Abstract

Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Uncontrolled Keywords:	Interleukin-18; Leishmania mexicana; Th2
Publisher:	Elsevier
ISSN:	1286-4579
Last Modified:	04 Jun 2017 03:02
URI:	http://orca.cf.ac.uk/id/eprint/15792

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