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Increased oral fibroblast lifespan is telomerase-independent

Enoch, Stuart, Wall, Ivan Bernard, Peake, Matthew Arnold, Davies, Lindsay Catrina, Farrier, Jerry N., Giles, Peter James, Baird, Duncan Martin, Kipling, David Glyn, Price, Patricia Elaine, Moseley, Ryan, Thomas, David William and Stephens, Philip 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88 (10) , pp. 916-921. 10.1177/0022034509342979

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Abstract

Oral mucosal wound-healing is characterized by rapid re-epithelialization and remodeling, with minimal scar formation. This may be attributed to the distinct phenotypic characteristics of the resident fibroblasts. To test this hypothesis, we investigated patient-matched oral mucosal and skin fibroblasts. Compared with skin fibroblasts, oral mucosal fibroblasts had longer proliferative lifespans, underwent more population doublings, and experienced senescence later, which was directly related to longer telomere lengths within oral mucosal fibroblasts. The presence of these longer telomeres was independent of telomerase expression, since both oral oral mucosal fibroblasts and skin fibroblasts were negative for active telomerase, as assessed according to the Telomeric Repeat Amplification Protocol. This study has demonstrated that, compared with skin fibroblasts, oral mucosal fibroblasts are 'younger', with a more embryonic/fetal-like phenotype that may provide a notable advantage for their ability to repair wounds in a scarless fashion.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
R Medicine > RK Dentistry
Uncontrolled Keywords: telomeres; fibroblast; aging; oral mucosa
Publisher: Sage
ISSN: 0022-0345
Last Modified: 04 Apr 2019 23:23
URI: http://orca.cf.ac.uk/id/eprint/15844

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