Real world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: A retrospective multicentre cohort study

Papathanasiou, Athanasios, Hibbert, Aimee, Tallantyre, Emma ORCID: https://orcid.org/0000-0002-3760-6634, Harding, Katharine, Panneer Selvam, Adithya, Morgan, Matthew, Quainton, Charlotte, Talaei, Maryam, Arun, Tarunya, Ingram, Gillian, Law, Graham R. and Evangelou, Nikos 2023. Real world annualized relapse rates from contemporary multiple sclerosis clinics in the UK: A retrospective multicentre cohort study. Neurological Sciences 44 , pp. 3629-3635. 10.1007/s10072-023-06838-1 Item availability restricted.

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Abstract

Background Annualized relapse rate (ARR) is used as an outcome measure in multiple sclerosis (MS) clinical trials. Previous studies demonstrated that ARR has reduced in placebo groups between 1990 and 2012. This study aimed to estimate real-world ARRs from contemporary MS clinics in the UK, in order to improve the feasibility estimations for clinical trials and facilitate MS service planning. Methods A multicentre observational, retrospective study of patients with MS from 5 tertiary neuroscience centres in the UK. We included all adult patients with a diagnosis of MS that had a relapse between 01/04/2020 and 30/06/2020. Results One hundred thirteen out of 8783 patients had a relapse during the 3-month study period. Seventy-nine percent of the patients with a relapse were female, the mean age was 39 years, and the median disease duration was 4.5 years; 36% of the patients that had a relapse were on disease-modifying treatment. The ARR from all study sites was estimated at 0.05. The ARR for relapsing remitting MS (RRMS) was estimated at 0.08, while the ARR for secondary progressive MS (SPMS) was 0.01. Conclusions We report a lower ARR compared to previously reported rates in MS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Springer
ISSN:	1590-1874
Date of First Compliant Deposit:	11 May 2023
Date of Acceptance:	2 May 2023
Last Modified:	22 Nov 2023 16:25
URI:	https://orca.cardiff.ac.uk/id/eprint/159409

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