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Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms

Percival, S. L., Hill, Katja E., Malic, Sladjana, Thomas, David William and Williams, David Wynne 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19 (1) , pp. 1-9. 10.1111/j.1524-475X.2010.00651.x

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Abstract

The application of antimicrobials in the management of wounds is a complex procedure requiring appropriate clinical decision making, judgment and a thorough understanding of antimicrobial therapies, together with their potential disadvantages. There is considerable direct and indirect evidence for the presence of bacterial biofilms in the chronic wound bed, and it has been demonstrated that bacteria within these biofilms may exhibit both specific and nonspecific antimicrobial tolerance. The antimicrobial tolerance of biofilms is a major concern in the treatment of both infected and nonhealing chronic wounds and an understanding of the mechanisms involved is of fundamental importance in managing wound infections and developing future wound management strategies. The aim of this review is therefore to provide an overview of our current understanding of the mechanisms by which bacteria in wound biofilms can resist conventional antibiotic and antibacterial therapies which is very important to wound healing. © 2011 by the Wound Healing Society.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Systems Immunity Research Institute (SIURI)
Publisher: Wiley
ISSN: 1067-1927
Last Modified: 04 Feb 2019 22:36
URI: http://orca.cf.ac.uk/id/eprint/16015

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Cited 43 times in Web of Science. View in Web of Science.

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