Htet, Z. M. and Tallantyre, E. ORCID: https://orcid.org/0000-0002-3760-6634
2023.
Optic neuritis and MOGAD.
Journal of Neurology
270
(6)
, 3278–3279.
10.1007/s00415-023-11738-7
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Abstract
Optic neuritis (ON) is one of the most common causes of monocular visual loss but has several mimics that result in relatively frequent misdiagnosis. In recent years, there has been a growing recognition of the distinct entities of antibody-associated ON (associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) or Aquaporin 4 (AQP4), which have implications for treatment. Some cases of ON represent the first symptom of multiple sclerosis, whilst other cases of ON are (para)infectious or associated with alternate causes of more widespread systemic inflammatory disease. The prevalence of these aetiologies varies according to age, geographical location, and ethnicity. Imaging of the optic nerve using MRI and OCT has continued to improve over recent years as well as becoming more available and has facilitated diagnosis. However, consensus definitions for classification and diagnostic criteria have been lacking. In this month’s journal club, we present a consensus paper that proposes new criteria for the diagnosis of ON, and two papers reporting the clinical features of MOG-antibody-associated disease.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
Publisher: | Springer |
ISSN: | 0340-5354 |
Date of First Compliant Deposit: | 10 July 2023 |
Date of Acceptance: | 17 April 2023 |
Last Modified: | 06 Jan 2024 19:52 |
URI: | https://orca.cardiff.ac.uk/id/eprint/160889 |
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