Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Macrolides and community-acquired pneumonia: is quorum sensing the key?

Wise, Matthew Peter, Williams, David Wynne, Lewis, Michael Alexander Oxenham and Frost, Paul John 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key? Critical care (London, England) 14 (4) , 181. 10.1186/cc9084

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (128kB) | Preview

Abstract

Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Medicine
Publisher: BioMed Central Ltd
ISSN: 1364-8535
Date of First Compliant Deposit: 30 March 2016
Last Modified: 05 May 2019 19:21
URI: http://orca.cf.ac.uk/id/eprint/16120

Citation Data

Cited 5 times in Google Scholar. View in Google Scholar

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 5 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics