Maternal type 1 diabetes and relative protection against offspring transmission

Allen, Lowri A., Taylor, Peter N. ORCID: https://orcid.org/0000-0002-3436-422X, Gillespie, Kathleen M., Oram, Richard A. and Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462 2023. Maternal type 1 diabetes and relative protection against offspring transmission. Lancet Diabetes and Endocrinology 11 (10) , pp. 755-767. 10.1016/S2213-8587(23)00190-0

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Abstract

Type 1 diabetes is around twice as common in the offspring of men with type 1 diabetes than in the offspring of women with type 1 diabetes, but the reasons for this difference are unclear. This Review summarises the evidence on the rate of transmission of type 1 diabetes to the offspring of affected fathers compared with affected mothers. The findings of nine major studies are presented, describing the magnitude of the effect observed and the relative strengths and weaknesses of these studies. This Review also explores possible underlying mechanisms for this effect, such as genetic mechanisms (eg, the selective loss of fetuses with high-risk genes in mothers with type 1 diabetes, preferential transmission of susceptibility genes from fathers, and parent-of-origin effects influencing gene expression), environmental exposures (eg, exposure to maternal hyperglycaemia, exogenous insulin exposure, and transplacental antibody transfer), and maternal microchimerism. Understanding why type 1 diabetes is more common in the offspring of men versus women with type 1 diabetes will help in the identification of individuals at high risk of the disease and can pave the way in the development of interventions that mimic the protective elements of maternal type 1 diabetes to reduce the risk of disease in individuals at high risk.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	2213-8587
Date of First Compliant Deposit:	25 July 2023
Date of Acceptance:	16 June 2023
Last Modified:	01 Mar 2024 05:47
URI:	https://orca.cardiff.ac.uk/id/eprint/161214

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