Advance consent in acute stroke trials: survey of Canadian Research Ethics Board chairs

Seeger, Rena, Udoh, Ubong, Dewar, Brian, Nicholls, Stuart, Fedyk, Mark, Fahed, Robert, Perry, Jeff, Hill, Michael D., Menon, Bijoy, Swartz, Richard H., Poppe, Alexandre Y., Gocan, Sophia, Brehaut, Jamie, Dainty, Katie, Shepherd, Victoria ORCID: https://orcid.org/0000-0002-7687-0817, Dowlatshahi, Dar and Shamy, Michel 2023. Advance consent in acute stroke trials: survey of Canadian Research Ethics Board chairs. Canadian Journal of Neurological Sciences 10.1017/cjn.2023.247

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Abstract

dvance consent could allow individuals at high risk of stroke to provide consent before they might become eligible for enrollment in acute stroke trials. This survey explores the acceptability of this novel technique to Canadian Research Ethics Board (REB) chairs that review acute stroke trials. Responses from 15 REB chairs showed that majority of respondents expressed comfort approving studies that adopt advance consent. There was no clear preference for advance consent over deferral of consent, although respondents expressed significant concern with broad rather than trial-specific advance consent. These findings shed light on the acceptability of advance consent to Canadian ethics regulators.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine Centre for Trials Research (CNTRR)
Publisher:	Cambridge University Press
ISSN:	0317-1671
Date of First Compliant Deposit:	5 September 2023
Date of Acceptance:	22 June 2023
Last Modified:	07 Sep 2023 11:42
URI:	https://orca.cardiff.ac.uk/id/eprint/162243

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