Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women

Steventon, Jessica J., Lancaster, Thomas M., Simmonds Baker, Emily, Bracher-Smith, Matthew, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Ruth, Katherine S., Davies, William ORCID: https://orcid.org/0000-0002-7714-2440, Caseras, Xavier ORCID: https://orcid.org/0000-0002-8490-6891 and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158 , 106393. 10.1016/j.psyneuen.2023.106393

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Abstract

Medial temporal lobe (MTL) atrophy is correlated with risk and severity of Alzheimer disease (AD) pathology and cognitive decline. Increasing evidence suggest that oestrogens affect the aging of MTL structures. Here we investigate the relationship between reproductive hormone exposure, polygenic scores for AD risk and oestradiol concentration, MTL anatomy and cognitive performance in postmenopausal women. To this end, we used data from 10,924 female participants in the UK Biobank from whom brain MRI and genetic data were available. We fitted linear regression models to test whether the volume of structures comprising the MTL were predicted by a) timing related to menopause, b) the use and timing of hormone replacement therapy (HRT) and c) polygenic scores for AD risk and oestradiol concentration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	0306-4530
Funders:	Wellcome Trust
Date of First Compliant Deposit:	20 September 2023
Date of Acceptance:	17 September 2023
Last Modified:	31 Oct 2023 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/162631

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