The translation of psychiatric genetics findings to the clinic

Kendall, Kimberley ORCID: https://orcid.org/0000-0002-6755-6121, Duffin, Donna, Doherty, Joanne, Irving, Rachel, Procter, Annie and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2023. The translation of psychiatric genetics findings to the clinic. Schizophrenia Research 10.1016/j.schres.2023.10.024

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Abstract

Mental health and neurodevelopmental disorders are highly heritable and can affect morbidity and mortality. A large, growing body of evidence has implicated both common and rare variation in the risk of these disorders. Testing for rare variants, such as copy number variants, has been available in clinical practice for some time in the context of developmental disorders. However, until recently, individuals with mental health and neurodevelopmental disorders in the UK have not tended to access genetic counselling and testing. Here, we describe the development of the All Wales Psychiatric Genomics Service, a collaborative effort between psychiatric and clinical genetics services and the first of its kind in the UK. We provide an overview of the structure and function of the service, our referral criteria, a summary of the 40 referrals we have received to date and our future plans.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	0920-9964
Date of First Compliant Deposit:	25 October 2023
Date of Acceptance:	24 October 2023
Last Modified:	09 Nov 2023 16:41
URI:	https://orca.cardiff.ac.uk/id/eprint/163488

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