UK Kidney association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE

Roddick, Alistair J., Wonnacott, Alexa ORCID: https://orcid.org/0000-0002-0968-4248, Webb, David, Watt, Angela, Watson, Michael A., Staplin, Natalie, Riding, Alex, Lioudaki, Eirini, Kuverji, Apexa, Kossi, Mohsen El, Holmes, Patrick, Holloway, Matt, Fraser, Donald ORCID: https://orcid.org/0000-0003-0102-9342, Carvalho, Chris, Burton, James O., Bhandari, Sunil, Herrington, William G. and Frankel, Andrew H. 2023. UK Kidney association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE. BMC Nephrology 24 (1) , 310. 10.1186/s12882-023-03339-3

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Abstract

Large placebo-controlled trials have demonstrated kidney and cardiovascular clinical benefits of SGLT-2 inhibitors. Data from the EMPA-KIDNEY and DELIVER trials and associated meta-analyses triggered an update to the UK Kidney Association Clinical Practice Guideline on Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibition in Adults with Kidney Disease. We provide a summary of the full guideline and highlight the rationale for recent updates. The use of SGLT-2 inhibitors in people with specific medical conditions, including type 1 diabetes, kidney transplants, and people admitted to hospital with heart failure is also considered, along with Recommendations for future research and Recommendations for implementation. A full “lay” summary of the guidelines is provided as an appendix to ensure that these guidelines are accessible and understandable to people who are not medical professionals.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	BioMed Central
ISSN:	1471-2369
Date of First Compliant Deposit:	26 October 2023
Date of Acceptance:	19 September 2023
Last Modified:	26 Oct 2023 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/163515

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