Retinal oxygenation with conventional 100ms vs short-pulse pan-retinal laser photocoagulation

Gallagher, Kevin, Ostler, Timothy and Woolley, Thomas ORCID: https://orcid.org/0000-0001-6225-5365 2024. Retinal oxygenation with conventional 100ms vs short-pulse pan-retinal laser photocoagulation. Ophthalmic Surgery, Lasers and Imaging Retina 55 (1) , pp. 40-45. 10.3928/23258160-20231114-01 Item availability restricted.

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Abstract

Background: Conventional (100ms) pan-retinal photocoagulation (PRP) laser burns are larger than short-pulse (10-20ms) PRP burns. This study investigates the effect of PRP burns of different sizes on retinal oxygenation. Methods: A mathematical model using COMSOL Multiphysics 6 was employed to create a 3D abstraction of the coupled biology of the choroid, photoreceptor, and retinal tissues. Laser burn sizes were varied in the model, specifically considering burn diameters of 500μm, 250μm, and 125μm, while keeping the total burn area constant. Results: Total increase in retinal oxygenation was the same for different burn sizes, but the oxygen distribution differed. Smaller burns resulted in a more even lateral oxygen distribution but with reduced penetration into the inner retina. Conclusions: Conventional and short-pulse PRP may affect retinal oxygenation differently, even when total burn area is the same. Further investigation into optimum burn size and pattern is required.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences Mathematics
Subjects:	Q Science > QA Mathematics Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RE Ophthalmology
Publisher:	Slack
ISSN:	2325-8160
Date of First Compliant Deposit:	13 November 2023
Date of Acceptance:	9 November 2023
Last Modified:	23 Jan 2024 22:36
URI:	https://orca.cardiff.ac.uk/id/eprint/163850

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