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The volume of the liver irradiated during breast radiotherapy

Courtier, Nicholas and Mundy, Lynn A. 2007. The volume of the liver irradiated during breast radiotherapy. Presented at: Society & College of Radiographers Radiotherapy Conference, Brighton, 1 February 2007.

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Abstract

Background and purpose: Loco-regional radiotherapy after breast conserving surgery significantly reduces the risk of recurrence1. Related radiation morbidity will depend on the volume of normal tissue irradiated and the dose delivered. Whilst much work has been concerned with minimising lung and cardiac doses2,3,4, there is no published evidence of the volume of the underlying liver/stomach irradiated. The study purpose was, to establish baseline dose-volume data for the liver and stomach. Any effect of breast size (as represented by tangential separation) on this dose-volume data was evaluated. Methodology: Organ dose volume histograms (DVH) were derived, from 3-dimensional treatment plans, for 14 women. DVH analysis enabled the determination of the volume of liver and stomach encompassed by, • the 50% isodose (representative of the primary radiation field boundary). • the 66% isodose (representative of a radiobiologically significant dose for a reference dose of 45Gy). Results: The volume of liver/stomach encompassed by the 50% and 66% isodoses were small, being ≤ 5% and ≤ 3.8% respectively. Positive trends were identified, that did not reach significance (p=0.160, >0.05), for a correlation between volume of liver/stomach irradiated and breast size. Conclusions: Women who have undergone breast conserving surgery do not receive primary radiation, to sufficiently large liver/stomach volumes, to cause serious morbidity; considering tolerance doses and volume effects for these organs. Approximately two thirds of patients did receive significant doses to a small volume of liver/stomach. This irradiation may be an additive or causative factor in the aetiology of any acute treatment related reactions.

Item Type: Conference or Workshop Item (Poster)
Date Type: Completion
Status: Unpublished
Schools: Healthcare Sciences
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information: 1st prize
Last Modified: 04 Jun 2017 03:04
URI: http://orca.cf.ac.uk/id/eprint/16417

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