Mechanochemical Cu(ii) complexes and propargylamine synthetic adventures †

Al Jomeh, Ghadah Abdullah S., McGown, Andrew, Richards, Emma ORCID: https://orcid.org/0000-0001-6691-2377, Tizzard, Graham J., Coles, Simon J., González-Méndez, Ramón, Dadswell, Chris, Spencer, John and Kostakis, George E. 2024. Mechanochemical Cu(ii) complexes and propargylamine synthetic adventures †. RSC Sustainability 2 (2) , pp. 528-535. 10.1039/d3su00315a

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Abstract

We synthesized and characterized known and new Cu(ii)–salen complexes and investigated their efficacy in yielding propargylamines (PAs) via an A3 coupling reaction mechanochemically. Although the method appears simple, we explicitly describe synthetic obstacles that urge unavoidable solvent use to isolate the molecular entities in high purity. The recovered complexes retain structure and catalytic efficacy, and a library of twenty-four known and unknown PAs are isolated in very good to excellent yields. The scope and limitations of this method are presented.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/3.0/, Start Date: 2024-01-09
Publisher:	Royal Society of Chemistry
ISSN:	2753-8125
Date of First Compliant Deposit:	17 January 2024
Date of Acceptance:	8 January 2024
Last Modified:	18 Mar 2024 13:14
URI:	https://orca.cardiff.ac.uk/id/eprint/165589

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