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Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growth-independent (K3) human breast cancer cells

Nicholson, Robert Ian, Gee, Julia Margaret Wendy, Francis, A. B., Manning, D. L., Wakeling, A. E. and Katzenellenbogen, B. S. 1995. Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growth-independent (K3) human breast cancer cells. Endocrine-Related Cancer 2 (1) , pp. 115-121. 10.1677/erc.0.0020115

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Abstract

INTRODUCTION During the last 7 years the Breast Cancer Group within the Tenovus Cancer Research Centre has maintained an involvement in the use of pure antioestrogens in two important areas of breast cancer research. First, their development as clinical agents, where we hoped to induce total oestrogen deprivation and thereby improve the effectiveness of first-line endocrine therapy (Nicholson et al. 1992, Nicholson 1993, Nicholson et al. 1993a, DeFriend et al. 1994, Nicholson et al. 1994c). Second, as pharmacological probes to investigate the cellular and molecular actions of oestrogens and tamoxifen (Nicholson et al. 1988, Weatherill et al. 1988, Wilson et al. 1990). Implicit in each of these areas of research are questions associated with the impact which pure antioestrogens might have on the therapy of endocrine-resistant states and whether resistance develops as a consequence of incomplete oestrogen withdrawal, with tumour cells more efficiently utilising either a reduced oestrogenic pool

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Publisher: Society for Endocrinology
ISSN: 1351-0088
Last Modified: 04 Jun 2017 03:07
URI: http://orca.cf.ac.uk/id/eprint/17136

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