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Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression

Jones, Simon Arnett, Jones, Gareth Wyn, Williams, Anwen Sian and Nowell, Mari Ann 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8 (3) , pp. 235-246.

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Abstract

The humanized anti-interleukin (IL)-6 receptor antibody Tocilizumab is currently in Phase III clinical trials for use in autoimmune conditions such as rheumatoid arthritis and Crohn's disease. However do we fully appreciate the regulation of IL-6 responses in vivo, and understand the wider implications of IL-6 bioactivity in general physiology and inflammation? In the context of this review we will explore how IL-6 affects arthritis progression, and discuss the inflammatory mechanism governing IL-6 responsiveness. Specific attention will be given to the role of the soluble IL-6 receptor and we will discuss the merit of selectively targeting this soluble receptor as an alternative therapeutic strategy for clinically blocking IL-6 involvement in disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Cytokines, receptors, chemokines, inflammation, arthritis, leukocytes, gp130, tocilizumab
Publisher: Bentham Science
ISSN: 1875-5844
Last Modified: 16 Apr 2018 15:47
URI: http://orca.cf.ac.uk/id/eprint/17548

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