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Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives

Arshad, Afsheen, Osman, Hasnah, Bagley, Mark Christopher, Lam, Chan Kit, Mohamad, Suriyati and Zahariluddin, Anis Safirah Mohd 2011. Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives. European Journal of Medicinal Chemistry 46 (9) , pp. 3788-3794. 10.1016/j.ejmech.2011.05.044

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Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a–d and 15a–h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Elsevier
ISSN: 0223-5234
Last Modified: 19 Mar 2016 22:28

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