Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tissue-specific stem cell differentiation in an in vitro airway model

Prytherch, Zoë Cariad ORCID: https://orcid.org/0000-0003-0690-0184, Job, Claire Alison, Marshall, Hillary, Foster, Martyn and Berube, Kelly Ann ORCID: https://orcid.org/0000-0002-7471-7229 2011. Tissue-specific stem cell differentiation in an in vitro airway model. Macromolecular Bioscience 11 (11) , pp. 1467-1477. 10.1002/mabi.201100181

Full text not available from this repository.

Abstract

The respiratory tract is the primary site of exposure to airborne compounds, with the bronchial epithelium providing one of the first lines of defence. A growing need exists for an accurate in vitro model of the bronchial epithelium. Here, normal human bronchial epithelial (NHBE) cells cultured at an air/liquid interface create a fully differentiated, in-vivo-like model of the human bronchial epithelium. Developmental characterisation includes (i) trans-epithelial electrical resistance, (ii) morphology and (iii) bronchial cell specific stains/markers. It is concluded that the basal/progenitor cells create a pseudo-stratified, mucociliary NHBE model containing basal, serous, Clara, goblet and ciliated cells, reflective of the normal human bronchial epithelium (days 24–33 ALI culture).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: bioengineering; biomimetics; human airway epithelium; in vitro models; tissue engineering
Additional Information: Article first published online: 12 OCT 2011
Publisher: Wiley-Blackwell
ISSN: 1616-5187
Related URLs:
Last Modified: 19 Oct 2022 08:33
URI: https://orca.cardiff.ac.uk/id/eprint/18215

Citation Data

Cited 38 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item