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Rotation in the 6-OHDA-lesioned rat

Dunnett, Stephen Bruce and Torres, Eduardo Miguel 2011. Rotation in the 6-OHDA-lesioned rat. In: Lane, Emma Louise and Dunnett, Stephen Bruce eds. Animal Models of Movement Disorders, Vol. 1. Neuromethods, vol. 61. New York: Humana Press, pp. 299-315. (10.1007/978-1-61779-298-4_15)

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Abstract

Rotation is one of the most widely used tests in behavioural neuroscience. It is designed to detect motor turning and side biases in animals with lesions of basal ganglia circuits of the brain, and most notably ­following unilateral dopamine-depleting 6-OHDA lesions of the nigrostriatal bundle. When activated by stimulant or dopamine agonist drugs, rats and mice turn vigorously in circles for the duration of drug activity, yielding a reliable and easily quantifiable measure of the extent of the lesion and mechanism of drug action on the unbalanced dopamine system in the host brain. The design of automated rotometer test apparatus is discussed in detail, with advice for selecting the features most appropriate for different experimental applications. The selection of drugs, doses, time frames and testing protocols are then described, again in terms of the general principles that are readily adapted to particular experimental applications. Finally, a series of notes consider frequently asked questions related to practical issues involving drug selection, drug sensitisation, multiple testing and test spacing, and theoretical issues related to why and how does an animal rotate, and conditioning effects on the rotation response.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Rotation ; Rotometer ; Skilled turning ; Conditioned turning ; Amphetamine ; Apomorphine ; 6-OHDA lesions ; Unilateral lesions ; Motor asymmetry
Publisher: Humana Press
ISBN: 9781617792977
Related URLs:
Last Modified: 04 Jun 2017 03:13
URI: http://orca.cf.ac.uk/id/eprint/18286

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